Geneesmiddelenonderzoek

In samenwerking met specialisten van ZGT doet de ZGT Apotheek onderzoek naar nieuwe geneesmiddelen en therapieën. Dit onderzoek vindt plaats onder strenge regelgeving en registratie. De medisch ethische toetsingscommissie moet toestemming verlenen voor deze onderzoeken. De ziekenhuisapotheek organiseert de logistiek rond de trialmedicatie.

 

ZGT pharmacy research

As clinical research is one of the core tasks of the ZGT, the ZGT Pharmacy is both active within its own lines of research (incl. supporting clinical trials) as with that of other departments. The research performed in de ZGT Pharmacy is in line with the scientific themes of the ZGT and is focussed on:

  • Optimization of pharmacotherapy in post-bariatric surgery patients
  • Optimization of clinical drug-prescribing through interdisciplinairy intervention strategies (focus: cardiovascular agents and antimicrobial therapy)

 


2020

 

Publicaties 

 

Prospective validation of a model-informed precision dosing tool for vancomycin in intensive care patients.

ter Heine R, Keizer RJ, van Steeg K, Smolders EJ, van Luin M, Derijks HJ, de Jager CPC, Frenzel T, Brüggemann R
Br J Clin Pharmacol. 2020;1–10.

 

Therapeutic drug monitoring using saliva as matrix: an opportunity for linezolid, but challenge for moxifloxacin.

van den Elsen SHJ, Akkerman OW, Jongedijk EM, Wessels M, Ghimire S, van der Werf TS, Touw DJ, Bolhuis MS, Alffenaar JC.

Eur Respir J. 2020 May 7; 55(5):1901903.

 

Dose optimisation of first-line tuberculosis drugs using therapeutic drug monitoring in saliva: feasible for rifampicin, not for isoniazid.

van den Elsen SHJ, Akkerman OW, Wessels M, Jongedijk EM, Ghimire S, van der Werf TS, Bolhuis MS, Touw DJ, Alffenaar JC.

Eur Respir J. 2020 May 12; 55(6):2000803.

 

Prospective evaluation of improving fluoroquinolone exposure using centralised therapeutic drug monitoring (TDM) in patients with tuberculosis (PERFECT): a study protocol of a prospective multicentre cohort study.

van den Elsen SHJ, Sturkenboom MGG, Akkerman O, Barkane L, Bruchfeld J, Eather G, Heysell SK, Hurevich H, Kuksa L, Kunst H, Kuhlin J, Manika K, Moschos C, Mpagama SG, Muñoz Torrico M, Skrahina A, Sotgiu G, Tadolini M, Tiberi S, Volpato F, van der Werf TS, Wilson MR, Zúñiga J, Touw DJ, Migliori GB, Alffenaar J-W.

BMJ Open 2020; 10(6):e035350.

 

Cross-validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Quantification of Levofloxacin in Saliva.

Ghimire S, Jongedijk EM, van den Elsen SHJ, Wessels MA, Touw DJ, Alffenaar J-WC.

Journal of Applied Bioanalysis 2020; 6(2):68-70.

 

Therapeutic Drug Monitoring in Tuberculosis Treatment: the Use of Alternative Matrices and Sampling Strategies.

Proefschrift Rijksuniversiteit Groningen, 26 februari 2020, Groningen

van den Elsen SHJ

 

Presentaties

 

Onderzoek naar de financiële zelfstandigheid van DORP; Dutch Oncology Research Platform

Presentatie VvAA Business School in Zeist, 11 maart 2020 

Hummel K, Aalst van R, Henstra M, Boor G


 

2019

 

Publicaties

 

 

Posters        


 

2018 

 

Publicaties

 

 

Posters      


 

2017

 

Publicaties 

 

 

Posters       


 

2016

 

Publicaties

 

 

 Posters      


 

2015

 

Publicaties